New Polyether Triterpenoids from Laurencia viridis and Their Biological Evaluation

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Abstract: 

The red seaweed Laurencia viridis is a rich source of secondary metabolites derived from squalene. New polyethers, such as iubol (2), 22-hydroxy-15(28)- dehydrovenustatriol (3), 1,2-dehydropseudodehydrothyrsiferol (4), and secodehydrothyrsiferol (5) have been isolated and characterized from this alga. The structures were determined through the interpretation of NMR spectroscopic data and the relative configuration was proposed on the basis of NOESY spectrum and biogenetic considerations. All new compounds exhibited significant cytotoxic activity against a panel of cancer cell lines.

Author(s): 
Antonio Hernández Daranas
José Javier Fernández
Manuel Norte Martín
Faustino Mollinedo
Janny A. Villa-Pulgarin
Francisco Cen Pacheco
Keywords: 
Laurencia viridis
squalene
polyethers
cytotoxic activity
Link / Ref: 
ResearchGate
Attachment: 
PDF icon New Polyether Triterpenoids from Laurencia viridis and Their Biological Evaluation.pdf
Article Source: 
Mar. Drugs 2011 , 9 , 2220 - 2235
Category: 
Seaweed composition
Uses of Seaweeds: Miscellaneous